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Table 1. Using the Japanese eel testicular culture system, we found that advanced-stage germ cells undergo intense apoptosis and exhibit a strong signal for 8-hydroxy-2'-deoxyguanosine, an oxidative DNA damage marker, upon exposure to hypoxanthine (Hx)-generated reactive oxygen species (ROS), while spermatogonia remain unaltered. Spermatogonia are highly tolerant to ROS attack while advanced-stage germ cells such as spermatozoa, are much more susceptible. Low ROS, Hx treatment at the low dose (1 μM); High ROS, Hx treatment at the highest dose (100 μM).

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