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Fig. 15. Dose response of the β-galactosidase gene expression under the control of the hsp70 promoter to sodium arsenite. The transgenic embryos showing β-galactosidase activity in the eyes were counted, and 50% of the fish positive for β-galactosidase gene expression could be determined at 5 μM sodium arsenite (filled triangles), whereas lethality (50% lethal dose, LD50) following a 24-h arsenite treatment was observed at 560 μM (filled circles). This finding indicates that transgene expression is a more sensitive marker than lethality by approximately 100-fold.

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