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Fig. 5. Gene structure of the hsp70 genes in zebrafish and human genomes. (A) The zebrafish genome contains three copies of the hsp70 genes, and HSP70-a was the only heat-inducible member of the HSP70 family. The gene encoding HSP70-b is tandemly linked to the gene encoding HSP70-a on the zebrafish chromosome 16, and the gene encoding HSP70-ctg9500 is present on zebrafish chromosome 8 (Yamashita et al. 2004). Arrows indicate the heat-inducibility of these genes measured by RT-PCR (Yabu et al. unpublished). (B) The human genome contains five copies of the hsp70 and its related genes; hsp70-1, hsp70-2, and hsp70B' are heat-inducible, whereas Hsp70HOM and Hst70 are testis-specific.

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