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Fig. 2. Model of molecular chaperone functions of the HSP70 family. HSP70 and HSC70 function as intracellular chaperones for other proteins, regulating protein-protein interactions, such as protein folding, establishment of protein disassembly and rearrangement, prevention of protein aggregation, transport of target proteins into the intracellular compartments, and translocation of proteins across membranes (Welch and Feramisco 1985). MtHSP70 and GRP78 are localized to the mitochondria and the endoplasmic reticulum, respectively (Yamashita et al. 2004).

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