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Fig. 38. A model for H+ secretion and HCO3­ retention in MR cells of Osorezan dace exposed to acid water. NHE3 in the apical membrane excretes H+ in exchange for Na+, whereas the electrogenic NBC1 in the basolateral membrane provides HCO3­ for neutralization of plasma using the driving force generated by Na+/K+-ATPase and CA-II. Figure 11A from Taku Hirata, Toyoji Kaneko, Toshihiro Ono et al., Mechanism of acid adaptation of a fish living in a pH 3.5 lake, Am. J. Physiol. Regul. Integr. Comp. Physiol., 284, R1199­R1212, 2003; used with permission of The American Physiological Society.

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